Xin Wang,#1 Pengfei Li,#1 Ping Zhou,2 Yiyun Fu,2 Yutian Lai,1 and Guowei Che

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1Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, 610041 People’s Republic of China

2Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041 People’s Republic of China

Xin Wang, Email: moc.qq@958361914.

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Corresponding author.

#Contributed equally.

Received 2018 Aug 13; Accepted 2018 Dec 27.

Copyright © The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Associated Data

Data Availability Statement

All data generated or analyzed during this study are included in this published article.

Abstract

Background

Cystic lung lesions involving both lungs include a variety of diseases, such as pulmonary Langerhans cell histiocytosis, lymphangioleiomyomatosis, Birt Hogg Dubé syndrome and pulmonary metastasis [1]. Meningioma might occur in extracranial organs and pulmonary meningioma is the most reported since it introduced by Weiss et al. in 1952 [2]. The primary pulmonary meningioma (PPM) with metastasis was extremely rare, which usually presented as isolated nodules rather than bilateral lesions. We describe a patient with one major lesion and multiple cystic lesions scattered over both lungs. The major mass was diagnosed as primary pulmonary meningioma and other cystic lesions was classified as intrapulmonary metastasis after thoracoscopic surgery.

Case report

A 64-year-old female patient was admitted to our department for multiple pulmonary lesions discovered by health examination for 1 month. She was asymptomatic, in good health, and had no history of pulmonary or neurologic disease. She denied history of tuberculosis, and she was a non-smoker.

Chest computed tomography (CT) revealed multiple thin-, smooth-walled cysts or cystic nodules with solid component were scarred within the lung parenchyma, sized from 0.8 cm to 2 cm (Fig. 1a, c). Enhanced CT scan revealed a 3.4 cm (cm) rounded mass located in the right posterior mediastinum at the inferior pulmonary vein plane (Fig. ​(Fig.1b).1b). It showed slight enhancement in the enhanced CT scan. The result of preoperative brain magnetic resonance imaging was also negative.

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Fig. 1

a, c: CT revealed multiple cycstic lesions involving both lungs. b: Major mass located in the right posterior mediastinum. d: Lung biopsy was taken for pathological examination

Thoracoscopic lung resection was scheduled for this patient. During the operation, the larger mass, which enveloped by fat-like thin films, was located on the surface of right lower lobe rather than the mediastinum. The tumor was stripped out successfully with a right-angle electrode and we also wedge resected two cystic lesions for pathological examination (Fig. ​(Fig.11d).

Routine pathological examination of both major mass and cystic lesions revealed the tumor consisting of spindle cells arranged in swirls scattered with a small amount of typical psammoma body (Fig. 2a, b, c hematoxylin and eosin staining, X100). Immunohistochemical (IHC) staining was performed for both major mass and cystic lesions and all lesions were positive for epithelial membrane antigen (Fig. ​(Fig.2d,2d, X200), CD34(Fig. ​CD34(Fig.2e,2e, X100), progesterone receptor (PR), Ki-67 and negative for STAT6 and CD68. The Ki-67/MIB-1 labeling index was less than 2% (Fig. ​(Fig.2f,2f, X200).

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Fig. 2

a, b, c: Tumor consisted of spindle cells arranged in swirls, Hematoxylin & eosin, × 100. d: IHC staining of EMA was positive, X200. e: IHC staining of CD34 was positive, X100. f: IHC staining of Ki-67/MIB-1 was positive, X200

The patient underwent an uneventful postoperative course and no additional therapy was added for her.

Conclusion

Intrapulmonary metastasis from a primary pulmonary meningioma may manifest as multiple thin-walled cystic lesions on computed tomography. Differential diagnosis of cystic pulmonary disease should include this situation. Our case shows the new CT manifestation of metastatic primary pulmonary meningioma and the importance of immunomolecular analysis.

Discussion

The diagnosis of the PPM depends on pathological and radiological studies, and more importantly, excluding metastasis from central nervous system. It is frequently reported that intracranial meningioma could metastases to the lungs, but only one case reporting multiple primary pulmonary meningioma [3]. The radiology manifestation of almost all of the metastasis or primary pulmonary meningioma showed as well-circumscribed solid nodules or mass [4, 5]. We are not aware of previous reports of intrapulmonary metastasis from primary pulmonary meningioma presenting as multiple thin-walled cystic lesions scattered within the lung parenchyma.

The initial diagnosis of this patient was considered as mediastinal tumor with multiple thin-walled cysts involving bilateral lungs based on chest CT. These thin-walled cysts were suspected to be lymphangioleiomyomatosis or Langerhans cell histiocytosis for their radiology manifestations. Morphological and histological characters ruled out the possibility of lymphangioleiomyomatosis. And negative expression of IHC staining of CD68 ruled out the diagnosis of Langerhans cell histiocytosis. Other IHC markers, such as KI67/MIB-1, CD34 and PR evaluated at the same time because these markers are correlated with recurrence and metastasis4. The results of pathology examination suggested to be benign primary pulmonary meningioma, however, even benign meningioma could metastasize [6]. And of these rare metastatic benign diseases, Stefani et al. reported that an intracranial meningioma could metastasize to bilateral lungs presenting as defuse cystic lesions [7]. Given the above consideration, the scattered cystic lesions in our patient were classified as multiple intrapulmonary metastasis from primary pulmonary meningioma which has not previously been reported.

Acknowledgements

Abbreviations

Authors’ contributions

XW and PL designed the study and drafted the manuscript. YF and PZ performed the histological examination of the lung biopsy and was a major contributor in writing the manuscript. PL and GC revised the manuscript. All authors read and approved the final manuscript.

Notes

Contributor Information

Xin Wang, Email: moc.qq@958361914.

Pengfei Li, Email: moc.qq@219636377.

Ping Zhou, Email: moc.361@09gnipuohz.

Yiyun Fu, Email: moc.qq@7008130671.

Yutian Lai, Email: moc.qq@970828698.

Guowei Che, Phone: +86-2885422494, Email: moc.nuyila@xh_iewougehc.

References