Vaccines Targeting PSCK9 for the Treatment of Hyperlipidemia

Stefan Toth,1Dominik Pella,2 and Jan Fedacko3Author informationArticle notesCopyright and License informationDisclaimer Abstract Despite progress in both primary and secondary prevention, cardiovascular diseases (CVD) are still the largest group of ailments contributing to morbidity and mortality worldwide. Atherosclerotic changes, the primary pathological substrate for CVD, are closely related to hypercholesterolemia. Therefore, the treatment of hypercholesterolemia is a key […]

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Lung Protrusion: Tragic Consequence of a Knife Assault

Lung Protrusion refers to the exposure of lung parenchyma from a defect in the chest wall. This is a case of knife assault which caused lung evisceration. A 20-year-old presented to the Emergency Department with bilateral stab wounds in the thorax, causing lung protrusion. He also had exposed lung parenchyma on the left side. He […]

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Non-traumatic splenic rupture in a patient with Kasabach–Merritt syndrome

Jitesh Parmar,1 Behnam Shaygi,2 and Mike Nelson1 BMJ Case Rep. 2009; 2009: bcr08.2008.0792.Published online 2009 Mar 5. doi: 10.1136/bcr.08.2008.0792 PMCID: PMC3027749 PMID: 21686627 BACKGROUND Haemangiomas are vascular lesions resulting from abnormal proliferation of blood vessels. They are the most common paediatric neoplasm. Kasabach–Merritt syndrome (KMS) is a rare type of vascular lesion with peculiar characteristics. The diagnosis is based upon three basic findings: […]

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Giant solitary hydatid cyst of spleen—A case report

M.M. Pukar⁎ and Shabari M. Pukar 1. Introduction Hydatid disease (Echinococcosis) is a zoonotic infection caused by the larval form of parasites of tapeworm, Echinococcus granulosus. Humans are the accidental intermediate host in the development cycle of hydatid disease. It is an endemic disease in the sheep and cattle raising countries Middle East, North Africa, New Zealand, Australia, […]

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Reconstruction of massive full‐thickness abdominal wall defect: successful treatment with nonabsorbable mesh, negative pressure wound therapy, and split‐skin grafting

Dogu Aydin, 1 Ida Felbo Paulsen, 1 Vibeke Egerup Bentzen, 1 Sami Asadzadeh, 2 and Lisbet Rosenkrantz Hölmich Case Report In May 2014, a 51‐year‐old morbidly obese woman (BMI 48), suffering from non‐insulin‐dependent diabetes, presented at the emergency department with a 20‐year‐old incisional hernia that had become incarcerated. At admittance, the abdomen was described with horizontal and vertical scars from former surgery and a […]

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Scalp avulsion injury

Patient reportedly fell and hit her head on on a sharp rock, lacerating her scalp. The wound was thouroughly irrigated and debrided. Later the wound was closed with sutures and two drains were placed to minimize the chance of haematoma formation. Broad spectrum antibiotics were also given. Scalp lacerations are a common injury. Clinical evaluation […]

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Complications of thyroidectomy for large goiter

Toufik Berri1,& and Rachida Houari2 Patient and observation A 50-years-old woman, hypertensive, hospitalized for a large cervical mass appeared 30 years ago. In the family history, her mother, sisters and cousins underwent a surgery for MNG. Despite of the large volume of the mass, the patient never described signs of cervical compression whatsoever respiratory, digestive, laryngeal, vascular […]

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Orbital Floor Reconstruction with Free Flaps after Maxillectomy

Leela Mohan C. S. R. Sampathirao, MS, MCh,1 Krishnakumar Thankappan, MS, DNB, MCh,1 Sriprakash Duraisamy, MS, MCh,1 Naveen Hedne, MS, MCh,1 Mohit Sharma, MS, MCh,1 Jimmy Mathew, MS, MCh,1 and Subramania Iyer, MS, MCh, FRCS1 Results One hundred twenty-six patients underwent maxillectomy during the study period. Combined modality treatment with surgery followed by radiotherapy with or with or out chemotherapy was performed. […]

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Compartment Syndrome

Compartment syndrome is one of the true emergencies where timing is critical and every hour that passes matters. Compartment syndrome occurs when pressure in a confined space gets too high. This was compartment syndrome of the arm and forearm due to reperfusion injury that happened with the vessels being compressed for a long time then […]

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Orf infection

A 45-year-old man presented to the emergency department with an enlarging lesion on the left thumb. The lesion had first manifested as a targetoid papule 2 weeks earlier (Panel A) and had progressively enlarged (Panel B) without associated pain or sensory deficits. He reported that 3 weeks earlier he had had direct contact with sheep […]

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Neutrophilic Dermatosis

A 7-year-old girl presented to the emergency department with a 2-week history of fever and with several days of painful blisters on her arms, legs, and face. Two weeks earlier, she had completed a course of penicillin for tonsillitis. On examination, there were multiple bullae with erythematous bases on the legs (Panel A) and well-demarcated, […]

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A Very Long Foreign Body in the Bladder

Atsushi Imai, 1 Yuichiro Suzuki, 1 Yasuhiro Hashimoto, 1 ,* Atsushi Sasaki, 1 Hisao Saitoh, 1 and Chikara Ohyama 2 2. Case Summary The patient was a 49-year-old male with no history of any psychiatric disorder. Gross hematuria was noted. He underwent medical examination at the local emergency room and was referred to us for examination of a foreign body in the bladder, which had been identified […]

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Innovative treatment using tilapia skin as a xenograft for partial thickness burns after a gunpowder explosion

Edmar Maciel Lima-Junior,1 Manoel Odorico de Moraes Filho,2 Bruno Almeida Costa,2 Francisco Vagnaldo Fechine,2 Maria Elisabete Amaral de Moraes,2 Francisco Raimundo Silva-Junior,1 Maria Flaviane Araújo do Nascimento Soares,1 Marina Becker Sales Rocha,2 and Cybele Maria Philopimin Leontsinis1 CASE REPORT A 23-year-old male patient, with no comorbidities, arrived at a burn treatment center in Fortaleza, Brazil after a thermal injury caused by contact with flames […]

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Scalp expansion for giant cutis verticis gyrata secondary to cerebriform intradermal nevus

Wenfang Dong, Huan Wang, and Fei Fan Case report A 27-year-old woman was admitted to the hospital for evaluation of a huge black scalp macule (20 × 18 cm) with thinning of the overlying hair (Figure 1). The asymptomatic scalp macule first appeared upon her birth and gradually increased in size. On physical examination, the scalp macule was characterized by […]

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Aesthetic reconstruction of the severely disfigured burned face: a creative strategy for a “natural” appearance using pre-patterned autogenous free flaps

Elliott H. Rose Burns Trauma. 2015; 3: 16.Published online 2015 Sep 27. doi: 10.1186/s41038-015-0014-8PMCID: PMC4964145PMID: 27574662 A 10-year-old girl sustained 80 % TBSA burns during a crib fire as an infant in Columbia. She was abandoned by her biological parents and brought to the United States for treatment where she was adopted by caring foster parents. Prior to treatment at The […]

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The Woman With No Face

A SEVERE untreated facial condition has left a woman in India with large hanging growths which eclipse her entire face – causing local children to be scared of her. Khadija Khatoon, 23, from Kolkata, India, has what doctors believe to be neurofibromatosis – a catch-all term for a number of genetic disorders which cause tumours […]

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Successful Microsurgical Replantation of Scalp Amputation Using Medicinal and Chemical Leech Therapy: A Case Report

A 47-year-old woman presented to the hospital with a com- plete amputated scalp after her hair was caught in a laun- dry-packing machine. Compact compression dressing with gauze and elastic band was applied, owing to severe bleeding by completely ruptured both superficial temporal artery (STA) and superficial temporal vein (STV) (Fig. 1). The laceration ex- […]

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