Vaccines Targeting PSCK9 for the Treatment of Hyperlipidemia

Stefan Toth,1 Dominik Pella,2 and Jan Fedacko3 Author information Article notes Copyright and License information Disclaimer 1SLOVACRIN, Slovak Clinical Research Infrastructure Network, Pavol Jozef Safarik University, Trieda SNP 1, 040 11 Kosice, Slovakia 21st Department of Cardiology, East Slovak Institute of Cardiovascular Diseases, Faculty of Medicine, Pavol Jozef Safarik University, Ondavská 8, 040 11 Košice, […]

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Reconstruction of massive full‐thickness abdominal wall defect: successful treatment with nonabsorbable mesh, negative pressure wound therapy, and split‐skin grafting

Clin Case Rep. 2016 Oct; 4(10): 982–985. Published online 2016 Sep 7. doi: 10.1002/ccr3.649 PMCID: PMC5054475 PMID: 27761251 Reconstruction of massive full‐thickness abdominal wall defect: successful treatment with nonabsorbable mesh, negative pressure wound therapy, and split‐skin grafting Dogu Aydin, 1 Ida Felbo Paulsen, 1 Vibeke Egerup Bentzen, 1 Sami Asadzadeh, 2 and Lisbet Rosenkrantz Hölmich 1 […]

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RESECTABLE?

BRIAN CAMAZINE, MD – GENERAL SURGEONbriancamazine@gmail.comEarthwide Surgical Foundation Last trip on Aug 1, 2015,  I encountered an incredible case. A poor little girl with a horrific tumor of the face. I do not know why it was not treated earlier. She came on the last day of the trip and I decided to just examiner […]

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How does SARS-CoV-2 infection affect survival among patients with cardiovascular emergencies?

Abstract Objective A previous study revealed a preliminary trend towards higher in-hospital mortality in patients emergently admitted with acute stroke during the COVID-19 pandemic in Germany. The current study aims to further examine the possible impact of a confirmed SARS-CoV-2 infection on in-hospital mortality. Methods This was a retrospective analysis of health insurance claims data […]

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Isolated trochlear nerve palsy with midbrain hemorrhage

Summarized by: Granit Rudi, MD Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841378/ Copyright © Indian Journal of Ophthalmology. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The term “palsy” refers to partial loss of a nerve’s function. […]

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Hypertension

Hypertension or high blood pressure is a chronic medical condition in which the blood pressure in the arteries is higher than it should be. This requires the heart to work harder than normal to circulate blood through the blood vessels. Blood pressure       The pressure in the arteries  s depending on what the heart is doing. When the heart squeezes, pumping blood into the arteries, the pressure increases. When the heart relaxes, the pressure […]

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Focused assessment with sonography for trauma (eFAST exam)

Focused assessment with sonography in trauma (commonly abbreviated as FAST) is a rapid bedside ultrasound examination performed by surgeons, emergency physicians, and certain paramedics as a screening test for blood around the heart (pericardial effusion) or abdominal organs (hemoperitoneum) after trauma.[1] The four classic areas that are examined for free fluid are the perihepatic space […]

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Making the equivocal unequivocal: standardization of clean margins in diabetic foot osteomyelitis

Clin Diabetes Endocrinol. 2020; 6: 8. Published online 2020 May 20. doi: 10.1186/s40842-020-00096-2 PMCID: PMC7238583 PMID: 32477590 Abstract Background The prevalence of diabetes mellitus continues to rise. Diabetic foot ulcers with osteomyelitis are a diabetes-related complication presenting a significant burden to this cohort. A cure to diabetic foot osteomyelitis remains elusive and standard of care has […]

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Achieving postprandial glucose control with lixisenatide improves glycemic control in patients with type 2 diabetes on basal insulin: a post-hoc analysis of pooled data

Clin Diabetes Endocrinol. 2020; 6: 2. Published online 2020 Jan 14. doi: 10.1186/s40842-019-0088-5 PMCID: PMC6961286 PMID: 31956422 Associated Data Data Availability Statement Please contact author for data requests. Abstract Background To examine the impact on glycemic control of achieving postprandial glucose (PPG) target with lixisenatide, a once-daily glucagon-like peptide-1 receptor agonist approved in the US, in […]

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Isolated ACTH deficiency during single-agent pembrolizumab for squamous cell lung carcinoma: a case report

Clin Diabetes Endocrinol. 2020; 6: 1. Published online 2020 Jan 6. doi: 10.1186/s40842-019-0092-9 PMCID: PMC6945618 PMID: 31921440 Associated Data Data Availability Statement The data used in this current report are available from the corresponding author on reasonable request. Abstract Background The programmed cell death 1 (PD-1) inhibitor pembrolizumab is a promising agent for treatment of several […]

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The relationship between depression and risk of metabolic syndrome: a meta‐analysis of observational studies

Clin Diabetes Endocrinol. 2021; 7: 4. Published online 2021 Mar 2. doi: 10.1186/s40842-021-00117-8 PMCID: PMC7923824 PMID: 33648597 Associated Data Data Availability Statement The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Abstract Introduction The link between metabolic syndrome and depression has always been controversial. Different studies that […]

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Hypoglycemic episodes in hospitalized people with diabetes in Portugal: the HIPOS-WARD study

Clin Diabetes Endocrinol. 2021; 7: 2. Published online 2021 Jan 5. doi: 10.1186/s40842-020-00114-3 PMCID: PMC7786902 PMID: 33402217 Associated Data Data Availability Statement Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA’s data sharing policy, including restrictions, is available at http://engagezone.msd.com/ds_documentation.php. Requests for access to the clinical study data can be […]

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Reasons for discontinuing insulin and factors associated with insulin discontinuation in patients with type 2 diabetes mellitus: a real-world evidence study

Clin Diabetes Endocrinol. 2021; 7: 1. Published online 2021 Jan 5. doi: 10.1186/s40842-020-00115-2 PMCID: PMC7786496 PMID: 33402226 Associated Data Supplementary Materials Additional file 1: Supplemental Table 1. Patient Characteristics Part II. Supplemental Table 2. Most Common Combination of Reasons for Insulin Discontinuation. 40842_2020_115_MOESM1_ESM.docx (17K) GUID: 10C9DBA6-9661-495F-9FF7-A8CCB0F801E4 Data Availability Statement The datasets generated during and/or analyzed during the […]

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Ketogenic Diet-Induced Diabetic Ketoacidosis in a Young Adult with Unrecognized Type 1 Diabetes

Case Rep Endocrinol. 2021; 2021: 6620832. Published online 2021 Feb 8. doi: 10.1155/2021/6620832 PMCID: PMC7884107 PMID: 33628529 Associated Data Data Availability Statement The data used to support the findings of this study are available from the corresponding author upon request. Abstract Ketogenic diet, a very low-carbohydrate diet and high-fat diet, has emerged as a popular approach […]

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Three Successful Pregnancies in a Patient with Recurrent Cushing’s Disease

Case Rep Endocrinol. 2021; 2021: 5517303. Published online 2021 Feb 13. doi: 10.1155/2021/5517303 PMCID: PMC7899752 PMID: 33628528 Associated Data Data Availability Statement All data used in this case are available from the corresponding author upon reasonable request. Abstract The association of pregnancy and Cushing’s disease (CD) is rare. A 28-year-old woman was admitted for clinical suspicion […]

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Transient Hypophosphatemia: A Dangerous Event in Multiple Myeloma

Case Rep Endocrinol. 2021; 2021: 3609346. Published online 2021 Jan 16. doi: 10.1155/2021/3609346 PMCID: PMC7826227 PMID: 33510918 Associated Data Data Availability Statement No data were used to support this study. Abstract Patients with malignancies frequently experience multiple electrolyte disturbances. In multiple myeloma, hypercalcemia and hyperphosphatemia are one of the most common metabolic disturbances observed as part […]

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Silicone Breast Implants: A Rare Cause of Pleural Effusion

Case Rep Pulmonol. 2015; 2015: 652918. Published online 2015 Nov 26. doi: 10.1155/2015/652918 PMCID: PMC4674589 PMID: 26693375 Abstract Pleural effusions are one of the rarest complications reported in patients with silicone gel filled breast implants. The silicone implants have potential to provoke chronic inflammation of pleura and subsequent pulmonary complications such as pleural effusion. Herein, we […]

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Primary Pulmonary Malignant Fibrous Histiocytoma

Case Rep Pulmonol. 2015; 2015: 381276. Published online 2015 Mar 8. doi: 10.1155/2015/381276 PMCID: PMC4370101 PMID: 25838959 Abstract Malignant fibrous histiocytoma (MFH) is one of the most common adult soft tissue sarcomas. MFH is very aggressive and is most often found in the extremities and the retroperitoneum, but it can manifest at other sites. Though the […]

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