Congenital Langerhans-Cell Histiocytosis

A female infant delivered at term by cesarean section had a “blueberry muffin” rash at birth. On physical examination, multiple purple, papulonodular lesions measuring 5 to 10 mm in diameter were seen on her trunk, arms and legs, palms and soles, oral mucosa, and palpebral conjunctiva. There was no lymphadenopathy or hepatosplenomegaly, and the results […]

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Waning COVID super-immunity raises questions about Omicron

  NEWS 13 December 2021 Waning COVID super-immunity raises questions about Omicron The pairing of SARS-CoV-2 infection and vaccination against it confers powerful protection, but data from Israel show that that protection gradually declines. Max Kozlov Max Kozlov View author publications You can also search for this author in PubMed  Google Scholar   A man […]

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Angioedema, an unusual reaction to hair dye

Reginald Mzudumile Ngwanya,1,&Zandile Spengane,1 and Nonhlanhla Khumalo1 Summary of Drugs used: Hydrocortisone, Phenergan, Vitamin D, Calcium tablets, Chlorpheniramine maleate, Cetomacrogol cream, Clobetasol, Methylprednisolone Introduction Paraphenynlenediamine (PPD) a potent skin sensitizer is a cause of allergic contact dermatitis, a type-IV hypersensitivity reaction. It is a constituent of hair dyes and is also added to red henna thereby creating […]

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Disseminated Superficial Porokeratosis with Dermal Amyloid Deposits

M. Carlesimo,a A. Rossi,b L. Fidanza,a A. Narcisi,a,* M. La Pietra,a E. Mari,a C. Cacchi,c and G. Camplonea M. Carlesimo aU.O.C. Dermatology, II Unit University of Rome ‘Sapienza’, Rome, Italy Find articles by M. Carlesimo A. Rossi bDepartment of Dermatology and Venereology, I Unit University of Rome ‘Sapienza’, Rome, Italy Find articles by A. Rossi […]

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Two Case Reports of Life-Threatening Ethanol-Induced Anaphylaxis

Case Rep Dermatol. 2009 Jan-Dec; 1(1): 1–6. Published online 2009 Apr 29. doi: 10.1159/000209154 PMCID: PMC2875848 PMID: 20508822 S.L. Fernandoa,c,d,* and L.R. Clarkeb S.L. Fernando aDepartment of Allergy, Royal North Shore Hospital, Sydney, N.S.W., Australia cNorthern Clinical School, University of Sydney, Sydney, N.S.W., Australia dPaLMS Immunorheumatology Laboratory, Sydney, N.S.W., Australia Find articles by S.L. Fernando L.R. […]

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A Case of Ketron-Goodman Disease

M. Carlesimo,a A. Tammaro,a C. Cox,b E. Mari,a L. Fidanza,a A. Narcisi,a,* C. Cacchi,c and G. Camplonea M. Carlesimo aU.O.C. Dermatology, II School of Medicine University of Rome ‘Sapienza’, Rome, Italy Find articles by M. Carlesimo A. Tammaro aU.O.C. Dermatology, II School of Medicine University of Rome ‘Sapienza’, Rome, Italy Find articles by A. Tammaro […]

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Scientists Find a Natural Protein That Stops Allergies And Autoimmune Conditions

For the millions of us plagued by hypersensitive, overactive, or downright abusive immune systems, it can feel like you’re constantly fighting your own physical self. From incessant allergies to life-threatening anaphylaxis and debilitating autoimmune disease, the system that’s supposed to be protecting us can be problematic when it goes wrong. Now, we might be closer to […]

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Physiologic and Pharmacologic Effects of Corticosteroids

Corticosteroids are key regulators of whole-body homeostasis that provide an organism with the capacity to resist environmental changes and invasion of foreign substances. The effects of corticosteroids are widespread, including profound alterations in carbohydrate, protein, and lipid metabolism, and the modulation of electrolyte and water balance. Corticosteroids affect all of the major systems of the […]

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Jellyfish injuries

Lakkana Thaikruea & Potjaman Siriariyaporn  It is widely known that box jellyfish are one of the most venomous marine animals in the world [1]. Envenomation involves the physical discharge of venom into tissues. The venom is a complex mixture of polypeptides and proteins, including hemolytic, cardiotoxic and dermatonecrotic toxins The islands of Samui and Pha-ngan have the […]

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Anti-hypertension drug related Angioedema

Ian Wisecarver, Sanjay Kamboj, MD, David Galambos, Michelle Korah-Sedgwick, MD, Ross McCarron, MD, Fred Lopez, MD CASE PRESENTATION A 72 year-old African American man with a past medical history of hypertension, heart failure with reduced ejection fraction, and alcohol use presented to the emergency department (ED) with a chief complaint of a one day history […]

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Tongue Necrosis Secondary to Giant Cell Arteritis

Giant cell arteritis is a form of vasculitis involving the medium- and large-sized arteries that chiefly affects older people. Clinical findings are headache, jaw claudication, fever, pain, and thickening of the temporal artery. The most feared complication is visual loss due to impairment of the ophthalmic artery and posterior ciliary arteries. GCA occurs predominantly in […]

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Vogt–Koyanagi–Harada Syndrome – Case report

We report a 28-year-old HIV-negative Ugandan woman with no known chronic illness. She presented to the eye clinic at Mulago National Referral Hospital (Kampala, Uganda) with a 2-week history of sudden onset blurring of vision in both eyes, especially in the mornings. This was preceded by a 1-week history of low-grade intermittent fevers, sore throat, […]

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Ulcerative colitis in a Nigerian girl: A case report

Case presentation A 7 year old girl presented to the paediatric gastroenterology clinic at the Lagos State University Teaching Hospital (LASUTH), Ikeja with a history of prolonged diarrhoea of 10 weeks that progressed to frank haematochezia 2 weeks later. She also presented with abdominal pain weight loss of over 8 weeks duration. Stool was initially […]

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The kiss of death: a severe allergic reaction to a shellfish induced by a good-night kiss.

REPORT OF A CASE A 20-year-old woman presented to an emergency department of a Mayo Clinic-affiliated hospital with sudden onset of lip angioedema, throat swelling, diffuse flushing, urticaria, abdominal cramps, nausea, wheezing, severe dyspnea, and hypotension (noninvasive blood pressure level of 80/50 mm Hg) that developed immediately after kissing her boyfriend. Intramuscular diphenhydramine and methylprednisolone, […]

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